As far as friendships go things change even without the fame. People start moving on. I have a few friends that are married and are starting to have kids and I'm like 'Oh my goodness gracious - that's so insane.' I also have friends who are just doing their own thing which is cool.
What constitutes a real live human being is more of a mystery than ever these days and men each one of whom is a valuable unique experiment on the part of nature are shot down wholesale.