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For the first half of geological time our ancestors were bacteria. Most creatures still are bacteria and each one of our trillions of cells is a colony of bacteria.

The founders of a new colony whatever Utopia of human virtue and happiness they might originally project have invariably recognized it among their earliest practical necessities to allot a portion of the virgin soil as a cemetery and another portion as the site of a prison.

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The secret is not to give up hope. It's very hard not to because if you're really doing something worthwhile I think you will be pushed to the brink of hopelessness before you come through the other side.