Look at Gleason in The Honeymooners. He was humorous but the way he lived wasn't really humorous. He was a bus driver. Who wants to be a bus driver? He didn't have any money and he was not famous. But despite that the show is humorous.
I don't have a single complete show or movie or anything else that I could look at and say 'Nailed that one.' But endless dissatisfaction is I suppose what gets us out of bed in the morning.