The new industries are brainy industries and so-called knowledge workers tend to like to be near other people who are the same. Think of the City of Hollywood. People cluster. This means you have winning regions such as London and Cambridge and losing regions. The people who want to be top lawyers in Sunderland are hoovered up by London.
For most people we often marvel at the beauty of a sunrise or the magnificence of a full moon but it is impossible to fathom the magnitude of the universe that surrounds us.